职称/职务

副教授

研究方向

天然药物化学，有机合成方法学

邮箱

        [email protected];

        g[email protected]

学习工作经历

2020.09 –   指尖四川麻将 化学化工指尖四川麻将 ，副教授；

2016.12 – 2020.08 中国科指尖四川麻将 新疆理化所，研究员；

2016.07 – 2016.11 中国科指尖四川麻将 新疆理化所，副研究员；

2015.06 – 2016.06 上海师范大学生命与环境科学指尖四川麻将 ，讲师；

2012.07 – 2015.05 德国维尔茨堡大学药物化学与食品化学指尖四川麻将 ，博士研究生，药物化学专业；

2011.11 – 2012.06 德国雷根斯堡大学药学系，博士研究生，药物化学专业；

2004.09 – 2007.07 中国科指尖四川麻将 研究生院，新疆理化技术研究所，硕士研究生，有机化学专业

主要科研项目及成果

主要围绕天然产物，开展分离纯化，结构改造和药理学研究。代表性工作有：(1)通过对中国传统中药吴茱萸的活性成分——吴茱萸碱的结构修饰，发现了一个丁酰胆碱酯酶抑制剂，并具有神经保护作用；(2)发现了一种简单快速地制备吴茱萸次碱及其类似物的合成方法；(3)在化学上首次实现了从水飞蓟素到次大风子素的有效转化方法，并对水飞蓟素进行衍生化，得到的次大风素类化合物有较好的抗癌和抗炎效果；(4)合作开展了新疆一枝蒿中的特有的倍半萜生物碱——一枝蒿碱G及其相关异构体的全合成；(5)合作开展了药用蕨类植物的活性成分分离，结构改造及活性研究，得到了抗癌活性较好的先导化合物。迄今发表各类科研论文84篇，相关工作发表于Organic Letters，European Journal of Medicinal Chemistry，Phytomedicine，Bioorganic Chemistry，Journal of Molecular Structure， Current Topics in Medicinal Chemistry，ACS Chemical Neuroscience，Bioorganic & Medicinal Chemistry，Journal of Chromatography B，Phytochemistry Letters，Natural Product Research等期刊。申请发明专利20项, 其中14项已经获得专利授权。参编图书1部。目前正在开展天然产物的结构改造和药理学研究。主要的研究兴趣包括天然产物的分离、结构修饰及活性研究，有机合成方法学。2016年入选国家级高层次人才引进计划，2020年入选马鞍山市“龙马工程”高层次人才。目前主要的研究包括天然产物的分离、结构修饰及活性研究，新药合成，有机合成方法学。

近5年来主要期刊论文

(详细列表见: //orcid.org/0000-0002-5730-9549)

1. Nina Wang, Jianghao Xing, Axue Ge, Yanchun Sun, Liang Ma*, Chenlu Xia, Zi Liu, Xianwen Wang*, Guozheng Huang*. Combination of indoline with alepterolic acid produced potent anti-breast cancer agents. Bioorganic Chemistry, 2026, 169, 109373

//doi.org/10.1016/j.bioorg.2025.109373

2. Lian Ma, Yanchun Sun, Binbin Zhang, Zixuan Tong, Yating Jia, Peixin Wang, Bingbing Ou, Jianguo Cao^*, Guozheng Huang*. Design, synthesis, and mechanistic evaluation of alepterolic acid derivatives fused with indole and piperazine as anticancer agents targeting breast cancer. Molecular Diversity, 2026, published online as an early view.

//doi.org/10.1007/s11030-025-11406-0

3. Junping Chen, Maoni Ren, Liangyu Huang, Yuxia Lou, Xinyao Hou, Yuge Zhang, Guozheng Huang*, Jianguo Cao*. Challenges in chiral discrimination at the H-2 and H-10 positions of dihydrobenzofuran from Artemisia capillaris. Phytochemistry, 2026, 242, 114711.

//doi.org/10.1016/j.phytochem.2025.114711

4. Liang Ma, Shizhun Zhang, Xiuping Mao, Zhigang Lu, Zixuan Tong, Junhui Guo, Junfeng Hu, Kaili Chang, Zi Liu*, Guozheng Huang*. Synthesis and evaluation of 8-(benzyloxy)-5,7-dibromo-2-methylquinoline derivatives as inducers of apoptosis in triple-negative breast cancer MDA-MB-468 cells via MKK7-JNK pathway activations. Bioorganic Chemistry, 2025, 166, 109117.

href="//doi.org/10.1016/j.bioorg.2025.109117" //doi.org/10.1016/j.bioorg.2025.109117

5. Qianqian Ren, Yuemei Que, Xiaoran Min, Wenhao Mu, Dandan Ruan, Xiling Dai, Peixin Wang, Jianguo Cao*, Yanzi Yang*, Guozheng Huang*. Cumambrin B attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways in vitro and acute lung injury in vivo. Archiv der Pharmazie, 2025, 358(11), e70137.

//doi.org/10.1002/ardp.70137

6. Zhihui Zhu, Chenjun Shen, Jingtao Yuan, Chenying Jiang, Maowei Ni, Guozheng Huang, Hang Gao, Jiahui Lu, Huajun Zhao* Hydnocarpin D-induced miRNA-145-5p targeting SERPINE1 suppresses metastasis and angiogenesis in ovarian cancer via inhibiting vitronectin/integrin/FAK pathway. British Journal of Pharmacology, 2026, 183,1140–1152.

//doi.org/10.1111/bph.70251

7. Xin Wang^#, Lian Ma^#, Yanchun Sun, Zixuan Tong, Binbin Zhang, Yating Jia, Xiling Dai, Jianguo Cao*, Guozheng Huang*. Structural hybridization of alepterolic acid with piperazine-benzamide motifs yields potent anticancer agents. Bioorganic Chemistry, 2025, 165, 108931.

href="//doi.org/10.1016/j.bioorg.2025.108931" //doi.org/10.1016/j.bioorg.2025.108931

8. Liang Shen #, Wenhao Mu #, Peixin Wang, Maoni Ren, Yating Jia, Xiaoran Min, Jiajia He, Guozheng Huang*, Hui Shen*, Jianguo Cao*. New pterosins from Hypolepis punctata. Journal of Natural Medicines, 2025, 79, 1404–1412.

//doi.org/10.1007/s11418-025-01945-z

9. Long-Jing Wu, An-Qi Deng, Jing-Xin Liu*, Rui-Lian Lin, Ming-Fu Ye, Guozheng Huang*. Solid-state host-guest supramolecular complexes based on cucurbit[7]uril: Dual photochromic and fluorescent properties for advanced applications. Aggregate, 2025, 6 (10), e71145.

//doi.org/10.1002/agt2.70145

10. Binbin Zhang, Yating Jia, Jufen Yan, Jing Zhou*, Nigora Rustamova, Jianguo Cao*, Guozheng Huang*. Progress on the natural products and its derivatives containing ureido motif: structure and biological activity. Chemistry & Biodiversity, 2025, 22(12), e01153.

//doi.org/10.1002/cbdv.202501153

11. Kaili Chang, Chengyu Zhang, Xiuping Mao, Zixuan Tong, Liang Ma, Zi Liu*, Guozheng Huang*. Synthesis and biological evaluation of piperlongumine analogues containing indoline or tetrahydroquinoline as anticancer agents through apoptosis induction. Medicinal Chemistry Research, 2025, 34, 1052–1064.

//doi.org/10.1007/s00044-025-03399-0

12. Qianqian Ren, Lili Wang, Xin Wang, Xiaoran Min, Xiling Dai, Guozheng Huang*, Jianguo Cao*. 3-Oxo-11αH-germacra-1(10)E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced oxidative stress and inflammation in RAW264.7 cells via ROS/NF-κB/MAPK pathways. Journal of Natural Medicines, 2025, 79, 204-214.

//doi.org/10.1007/s11418-024-01854-7

13. Ting Gao, Xin Wang, Yan Liu, Yong Wu, Chao Niu*, Jianzu Shen, Zi Liu, Liang Ma, Jianguo Cao*, Guozheng Huang*. Anticancer activity of 4α-(cyclopropyl formylpiperazinyl)-4-deoxypodophyllotoxin and its mechanism of action. Journal of Molecular Structure, 2024, 1311, 138460.

//doi.org/10.1016/j.molstruc.2024.138460

14. Nina Wang, Li Qin, Zi Liu, Jianguo Cao, Jiayi Huang, Liang Ma*, Guozheng Huang*. Discovery of a pimaradiene that decreases viability of MDA-MB-468 cells through inhibition of EGFR signaling pathway. Chemistry & Biodiversity, 2024, 21(4), e202400288.

//doi.org/10.1002/cbdv.202400288

15. Baoxiang Wu, Xian-Yong Wei*, Nina Wang, Chenlu Xia, Rongrong Bao, Jianguo Cao, Zhi-Min Zong, Zi Liu, Liang Ma*, Guozheng Huang*. Synthesis and antiproliferative evaluation of phenylalkylamino-containing alepterolic acid derivatives. Journal of Molecular Structure, 2023, 135358.

//doi.org/10.1016/j.molstruc.2023.135358

16. Xiaoxiao Pei, Zeyi Zhang, Nina Wang, Guozheng Huang*, Xiaoran Min, Yanzi Yang *, Jianguo Cao*. Onychiol B attenuates lipopolysaccharide-induced inflammation via MAPK/NF-κB pathways and acute lung injury in vivo. Bioorganic Chemistry, 2023, 132, 106351.

//doi.org/10.1016/j.bioorg.2023.106351

参编图书

1. Chapter 7 “Anti-cancer hybrids”. Qingjie Zhao, Guozheng Huang*, in the book “Design of Hybrid Molecules for Drug Development”, edited by Michael Decker, published by Elsevier. 2017. ISBN: 978-0-08-101011-2. //doi.org/10.1016/B978-0-08-101011-2.00007-6